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Clinical Trial
. 2007 May 21;13(19):2747-51.
doi: 10.3748/wjg.v13.i19.2747.

Complications of high intensity focused ultrasound in patients with recurrent and metastatic abdominal tumors

Jian-Jun Li  1 , Guo-Liang Xu, Mo-Fa Gu, Guang-Yu Luo, Zhang Rong, Pei-Hong Wu, Jian-Chuan Xia
Affiliations
Clinical Trial

Complications of high intensity focused ultrasound in patients with recurrent and metastatic abdominal tumors

Jian-Jun Li et al. World J Gastroenterol. .

Abstract

Aim: To analyze the local and systemic complications of high intensity focused ultrasound (HIFU) for patients with recurrent and metastatic abdominal tumors.

Methods: From Aug 2001 to Aug 2004, 17 patients with recurrent and metastatic abdominal tumors were enrolled in this study. Real-time sonography was taken, and vital signs, liver and kidney function, skin burns, local reactions, and systemic effects were observed and recorded before, during, and after HIFU. CT and MRI were also taken before and after HIFU.

Results: All 17 patients had skin burns and pain in the treatment region; the next common complication was neurapraxia of the stomach and intestines to variable degrees. The other local and systemic complications were relatively rare. Severe complications were present in two patients; one developed a superior mesenteric artery infarction resulting in necrosis of the entire small intestines, and the other one suffered from a perforation in terminal ileum due to HIFU treatment.

Conclusion: Although HIFU is a one of noninvasive treatments for the recurrent and metastatic abdominal tumors, there are still some common and severe complications which need serious consideration.

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Figures

Figure 1
Figure 1
CT 2 months before HIFU shows a tumor mass in the upper abdomen (arrow), with the SMA running out from the center (arrowhead).
Figure 2
Figure 2
T1 weighted imaging of MRI 1 wk before HIFU shows a large tumor in the upper abdomen (arrow), with the SMA running out from the center of tumor (arrowhead).
Figure 3
Figure 3
The target tumor presented as a white coagulative necrosis in the exploratory laparotomy 3 d after HIFU (arrowhead), the purple ischemia of the necrotic small intestines are also shown (arrowhead), and the SMA turned out from the center of tumor (arrow).
See this image and copyright information in PMC

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