Review
doi: 10.1016/j.lfs.2007.05.005.
Epub 2007 May 21.
Alcohol-induced oxidative stress
Affiliations
- PMID: 17570440
- DOI: 10.1016/j.lfs.2007.05.005
Item in Clipboard
Review
Alcohol-induced oxidative stress
Life Sci.
.
Abstract
Alcohol-induced oxidative stress is linked to the metabolism of ethanol involving both microsomal and mitochondrial systems. Ethanol metabolism is directly involved in the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). These form an environment favourable to oxidative stress. Ethanol treatment results in the depletion of GSH levels and decreases antioxidant activity. It elevates malondialdehyde (MDA), hydroxyethyl radical (HER), and hydroxynonenal (HNE) protein adducts. These cause the modification of all biological structures and consequently result in serious malfunction of cells and tissues.
Similar articles
-
Oxidative stress and alcoholic liver disease.Semin Liver Dis. 2009 May;29(2):141-54. doi: 10.1055/s-0029-1214370. Epub 2009 Apr 22. Semin Liver Dis. 2009. PMID: 19387914 Review.
-
Green tea supplementation in rats of different ages mitigates ethanol-induced changes in brain antioxidant abilities.Alcohol. 2005 Oct;37(2):89-98. doi: 10.1016/j.alcohol.2005.12.003. Alcohol. 2005. PMID: 16584972
-
Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates.Toxicol Appl Pharmacol. 2009 Feb 1;234(3):326-38. doi: 10.1016/j.taap.2008.11.004. Epub 2008 Nov 20. Toxicol Appl Pharmacol. 2009. PMID: 19063909
-
Free radicals, metals and antioxidants in oxidative stress-induced cancer.Chem Biol Interact. 2006 Mar 10;160(1):1-40. doi: 10.1016/j.cbi.2005.12.009. Epub 2006 Jan 23. Chem Biol Interact. 2006. PMID: 16430879 Review.
-
Zinc inhibits ethanol-induced HepG2 cell apoptosis.Toxicol Appl Pharmacol. 2008 May 15;229(1):1-9. doi: 10.1016/j.taap.2007.11.019. Epub 2007 Dec 3. Toxicol Appl Pharmacol. 2008. PMID: 18396304
Cited by
-
Myeloperoxidase formation of PAF receptor ligands induces PAF receptor-dependent kidney injury during ethanol consumption.Free Radic Biol Med. 2015 Sep;86:179-90. doi: 10.1016/j.freeradbiomed.2015.05.020. Epub 2015 May 21. Free Radic Biol Med. 2015. PMID: 26003521 Free PMC article.
-
Alcohol Binge Drinking Selectively Stimulates Protein S-Glutathionylation in Aorta and Liver of ApoE -/- Mice.Front Cardiovasc Med. 2021 Mar 16;8:649813. doi: 10.3389/fcvm.2021.649813. eCollection 2021. Front Cardiovasc Med. 2021. PMID: 33796575 Free PMC article.
-
Embryonic hepatocyte transplantation for hepatic cirrhosis: efficacy and mechanism of action.World J Gastroenterol. 2012 Jan 28;18(4):309-22. doi: 10.3748/wjg.v18.i4.309. World J Gastroenterol. 2012. PMID: 22294837 Free PMC article.
-
The effects of insulin pre-administration in mice exposed to ethanol: alleviating hepatic oxidative injury through anti-oxidative, anti-apoptotic activities and deteriorating hepatic steatosis through SRBEP-1c activation.Int J Biol Sci. 2015 Apr 3;11(5):569-86. doi: 10.7150/ijbs.11039. eCollection 2015. Int J Biol Sci. 2015. PMID: 25892964 Free PMC article.
-
Sub-toxic Ethanol Exposure Modulates Gene Expression and Enzyme Activity of Antioxidant Systems to Provide Neuroprotection in Hippocampal HT22 Cells.Front Physiol. 2016 Jul 27;7:312. doi: 10.3389/fphys.2016.00312. eCollection 2016. Front Physiol. 2016. PMID: 27512374 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
