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. 2007;24(2):91-7.
doi: 10.1159/000103914. Epub 2007 Jun 14.

Structural correlates of apathy in Alzheimer's disease

Liana G Apostolova  1 , Gohar G Akopyan, Negar Partiali, Calen A Steiner, Rebecca A Dutton, Kiralee M Hayashi, Ivo D Dinov, Arthur W Toga, Jeffrey L Cummings, Paul M Thompson
Affiliations

Structural correlates of apathy in Alzheimer's disease

Liana G Apostolova et al. Dement Geriatr Cogn Disord. 2007.

Abstract

Background: Apathy is the most common noncognitive symptom in Alzheimer's disease (AD). The structural correlates of apathy in AD have not yet been described.

Methods: We analyzed magnetic resonance imaging data of 35 AD patients with and without apathy.

Results: There was a significant linear association between apathy severity and cortical gray matter atrophy in the bilateral anterior cingulate [Brodmann area (BA) 24; r = 0.39-0.42, p = 0.01] and left medial frontal cortex (BA 8 and 9; r = 0.4, p < 0.02). Left mean cingulate cortical thinning predicted the presence/absence of apathy at the trend level of significance.

Conclusion: Our study demonstrates a strong association between apathy and the integrity of medial frontal regions in AD.

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