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. 2007 Aug 15;155(3):265-9.
doi: 10.1016/j.pscychresns.2007.01.010. Epub 2007 Jun 14.

Influence of comorbid depression on fear in posttraumatic stress disorder: an fMRI study

Andrew H Kemp  1 , Kim Felmingham, Pritha Das, Gerard Hughes, Anthony S Peduto, Richard A Bryant, Leanne M Williams
Affiliations

Influence of comorbid depression on fear in posttraumatic stress disorder: an fMRI study

Andrew H Kemp et al. Psychiatry Res. .

Abstract

Posttraumatic Stress Disorder (PTSD) is thought to involve a dysregulation of medial prefrontal-amygdala activity in response to fear. PTSD studies, however, have been confounded by comorbid depression, which shows similar dysregulation. Amygdala and medial prefrontal activity was reduced in PTSD-depression compared to PTSD-alone samples, highlighting the need to account for comorbidity.

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