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Review
. 2007 Oct;15(10):1101-5.
doi: 10.1016/j.joca.2007.04.013. Epub 2007 Jun 14.

Lessons from genetic forms of osteoarthritis for the pathogenesis of the disease

Y Li  1 , L Xu, B R Olsen
Affiliations
Review

Lessons from genetic forms of osteoarthritis for the pathogenesis of the disease

Y Li et al. Osteoarthritis Cartilage. 2007 Oct.
No abstract available

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Figures

Figure 1
Figure 1
Diagram showing a proposed timeline for the progression of OA. At an early stage, activation of the collagen receptor DDR2 leads to upregulated expression of MMP13. This results in generation of fragments of collagen II and fibronectin in the territorial matrix. These fragments, as well as cytokines such as IL-1, further stimulate signaling pathways that induce MMP-13 expression. The result is a time-dependent increase in the degradation of the cartilage extracellular matrix.
See this image and copyright information in PMC

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