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Clinical Trial
. 2007 Jun;69(6):1165-9.
doi: 10.1016/j.urology.2007.02.039.

GSTM1 and GSTT1 polymorphisms and the risk of prostate cancer in a Caribbean population of African descent

Stéphane Mallick  1 , Marc Romana, Pascal Blanchet, Luc Multigner
Affiliations
Clinical Trial

GSTM1 and GSTT1 polymorphisms and the risk of prostate cancer in a Caribbean population of African descent

Stéphane Mallick et al. Urology. 2007 Jun.

Abstract

Objectives: To investigate whether the glutathione S-transferase polymorphisms GSTM1 and/or GSTT1 contribute to prostate cancer risk in a Caribbean population of African descent in Guadeloupe.

Methods: We performed a hospital-based case-control study with 134 prostate cancer patients and 134 cancer-free, age-matched control subjects. Epidemiologic data were collected using a standard questionnaire. Logistic regression was used to estimate odds ratios (ORs) and compute confidence intervals (CIs). Genotypes were determined by multiplex polymerase chain reaction.

Results: The frequency of the GSTM1-positive genotype was 81% in patients and 73% in control subjects, with an adjusted OR of 1.4 (95% CI 0.7 to 2.5). The frequency of the GSTT1-positive genotype was 78% in patients and 63% in control subjects, with an adjusted OR of 2.6 (95% CI 1.4 to 4.9).

Conclusions: A functional GSTT1 polymorphism may be associated with prostate cancer susceptibility in a Caribbean population of African descent.

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