Comment
doi: 10.1016/j.cell.2007.05.049.
Taking vesicular transport to the cilium
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- PMID: 17574016
- DOI: 10.1016/j.cell.2007.05.049
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Comment
Taking vesicular transport to the cilium
Cell.
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Abstract
Defects in protein trafficking within the cell body and cilia are thought to underlie the human disease Bardet-Biedl syndrome (BBS). In this issue, Nachury et al. (2007) reveal that a large complex of proteins implicated in BBS cooperates with Rabin8-the GTP exchange factor for the small GTPase Rab8-to promote cilia formation and presumably movement of membrane proteins from the cell into the cilium.
Comment on
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A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.Cell. 2007 Jun 15;129(6):1201-13. doi: 10.1016/j.cell.2007.03.053. Cell. 2007. PMID: 17574030
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