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Comment
. 2007 Jun 15;129(6):1043-5.
doi: 10.1016/j.cell.2007.05.048.

All roads lead to IKKepsilon

Reuven Agami  1
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All roads lead to IKKepsilon

Reuven Agami. Cell. .
Free article

Abstract

Extensive genetic alterations have been found in many epithelial malignancies. Using three complementary genetic approaches, Boehm et al. (2007) identify IKBKE--which encodes IKKepsilon, a component of the NF-kappaB pathway--as a breast cancer oncogene.

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  • Integrative genomic approaches identify IKBKE as a breast cancer oncogene.
    Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier JK, Hinkle G, Root DE, Roberts TM, Lander ES, Polyak K, Hahn WC. Boehm JS, et al. Cell. 2007 Jun 15;129(6):1065-79. doi: 10.1016/j.cell.2007.03.052. Cell. 2007. PMID: 17574021

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