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. 2007 Sep;196(3):157-64.
doi: 10.1007/s00430-007-0038-1. Epub 2007 Feb 16.

Serum levels of IgG to the peptide of HCV1b core at positions 35-44 correlated with persistent infection, while levels of IgG to the peptide of NS5A at positions 2132-2140 correlated with better prognosis in HCV-infected patients

Yukari Takao  1 , Akira Yamada, Shigeru Yutani, Takeharu Ono, Yumiko Nagao, Eiji Ando, Tatsuya Ide, Kyogo Itoh, Michio Sata
Affiliations

Serum levels of IgG to the peptide of HCV1b core at positions 35-44 correlated with persistent infection, while levels of IgG to the peptide of NS5A at positions 2132-2140 correlated with better prognosis in HCV-infected patients

Yukari Takao et al. Med Microbiol Immunol. 2007 Sep.

Abstract

We previously reported that two IgG Abs to the hepatitis C virus (HCV), anti-core 35-44 (C35) and anti-NS5A 2132-2140 (NS5A2132), existed in the sera of the majority of patients with HCV infection. This study investigated if measuring the two Abs would facilitate the prediction of a patient's prognosis. The serum levels of anti-C35 were found to correlate with persistent infection, while those of anti-NS5A2132 correlated with a better prognosis in HCV-infected patients. These results suggest that sequential measurement of the two Abs together may provide new information for the prediction of prognosis.

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