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Case Reports
. 2007 Jul;78(7):750-3.
doi: 10.1136/jnnp.2006.098798.

Amyotrophic lateral sclerosis with sensory neuropathy: part of a multisystem disorder?

Jeremy D Isaacs  1 , Andrew F Dean, Christopher E Shaw, Ammar Al-Chalabi, Kerry R Mills, P Nigel Leigh
Affiliations
Case Reports

Amyotrophic lateral sclerosis with sensory neuropathy: part of a multisystem disorder?

Jeremy D Isaacs et al. J Neurol Neurosurg Psychiatry. 2007 Jul.

Abstract

Sensory involvement is thought not to be a feature of amyotrophic lateral sclerosis (ALS). However, in the setting of a specialist motor neuron disease clinic, we have identified five patients with sporadic ALS and a sensory neuropathy for which an alternative cause could not be identified. In three individuals, sensory nerve biopsy was performed, demonstrating axonal loss without features of an alternative aetiology. These findings support the hypothesis that ALS is a multisystem neurodegenerative disorder that may occasionally include sensory neuropathy among its non-motor features.

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Conflict of interest statement

Competing interests: None.

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