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Review
. 2007 Jul;36(7):1036-45.
doi: 10.1039/b611177g. Epub 2007 Apr 27.

Regioselective (site-selective) functionalization of unsaturated halogenated nitrogen, oxygen and sulfur heterocycles by Pd-catalysed cross-couplings and direct arylation processes

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Review

Regioselective (site-selective) functionalization of unsaturated halogenated nitrogen, oxygen and sulfur heterocycles by Pd-catalysed cross-couplings and direct arylation processes

Ian J S Fairlamb. Chem Soc Rev. 2007 Jul.

Abstract

This tutorial review focuses on several practical synthetic transformations utilising palladium catalysis that facilitate the synthesis of functionalized unsaturated heterocycles in a regioselective (site-selective) manner. Cross-couplings of electron-deficient, electron-neutral and electron-rich unsaturated halogenated heterocycles with various organometallic reagents, and other types of nucleophiles, are detailed. Direct arylation of electron-rich unsaturated heterocyclic compounds by C-H functionalization is also presented.

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