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Review
. 1991 Sep;10(1):1-8.
doi: 10.1007/BF02924248.

Perspectives of CCK antagonists in pancreatic research. Part II. Experimental studies

T Takács  1 , A Pap
Affiliations
Review

Perspectives of CCK antagonists in pancreatic research. Part II. Experimental studies

T Takács et al. Int J Pancreatol. 1991 Sep.

Abstract

In this article, the effects of different classes of cholecystokinin (CCK) receptor antagonists in CCK-related physiological processes of the pancreas have been discussed. Both glutaramic acid derivatives and natural (benzodiazepine) analogs are potent, competitive antagonists of peripheral CCK receptors. These compounds thus provide a powerful tool for investigating the physiological and pharmacological actions of CCK in the gastrointestinal system, and have already clarified the role of CCK in pancreatic secretion and trophism or growth.

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