Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2007 Jul;105(1):79-82.
doi: 10.1213/01.ane.0000265849.33203.60.

Rapid recovery from sevoflurane and desflurane with hypercapnia and hyperventilation

Derek J Sakata  1 , Nishant A Gopalakrishnan, Joseph A Orr, Julia L White, Dwayne R Westenskow
Affiliations
Comparative Study

Rapid recovery from sevoflurane and desflurane with hypercapnia and hyperventilation

Derek J Sakata et al. Anesth Analg. 2007 Jul.

Abstract

Background: Hypercapnia with hyperventilation shortens the time between turning off the vaporizer (1 MAC) and when patients open their eyes after isoflurane anesthesia by 62%.

Methods: In the present study we tested whether a proportional shortening occurs with sevoflurane and desflurane.

Results: Consistent with a proportional shortening, we found that hypercapnia with hyperventilation decreased recovery times by 52% for sevoflurane and 64% for desflurane (when compared with normal ventilation with normocapnia).

Conclusion: Concurrent hyperventilation to rapidly remove the anesthetic from the lungs and rebreathing to induce hypercapnia can significantly shorten recovery times and produce the same proportionate decrease for anesthetics that differ in solubility.

PubMed Disclaimer

Publication types