doi: 10.1002/art.1780190116.
Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure
- PMID: 175804
- DOI: 10.1002/art.1780190116
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Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure
Arthritis Rheum.
1976 Jan-Feb.
Abstract
Four patients with chondrocalcinosis of the knees volunteered for joint lavage. Preliminary experiments indicated that disodium EDTA and magnesium ions were potent solubilizers of CPPD crystals. The procedure was a therapeutic failure in that insignificant amounts of CPPD were removed and all 4 subjects developed postlavage attacks of pseudogout. It is hypothesized that the acute attack of pseudogout is a result of crystal shedding and may be triggered by any factor that enhances CPPD solubility.
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