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. 1976 Jan-Feb;19(1):93-7.
doi: 10.1002/art.1780190116.

Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure

R M Bennett, J R Lehr, D J McCarty

Crystal shedding and acute pseudogout. An hypothesis based on a therapeutic failure

R M Bennett et al. Arthritis Rheum. 1976 Jan-Feb.

Abstract

Four patients with chondrocalcinosis of the knees volunteered for joint lavage. Preliminary experiments indicated that disodium EDTA and magnesium ions were potent solubilizers of CPPD crystals. The procedure was a therapeutic failure in that insignificant amounts of CPPD were removed and all 4 subjects developed postlavage attacks of pseudogout. It is hypothesized that the acute attack of pseudogout is a result of crystal shedding and may be triggered by any factor that enhances CPPD solubility.

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