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. 2007 Jul 19;9(15):2879-82.
doi: 10.1021/ol071080f. Epub 2007 Jun 20.

C-C bond-forming reactions via Pd-mediated decarboxylative alpha-imino anion generation

Andrew A Yeagley  1 , Jason J Chruma
Affiliations

C-C bond-forming reactions via Pd-mediated decarboxylative alpha-imino anion generation

Andrew A Yeagley et al. Org Lett. .

Abstract

Alpha-imino anions are generated under neutral reaction conditions via a Pd-mediated decarboxylation of allyl diphenylglycinate imines with concomitant formation of a pi-allylpalladium species. The resulting delocalized anion can attack the pi-allyl-Pd(II) species or be intercepted by aldehydes to afford homoallylic amines or protected 1,2-amino alcohols, respectively.

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