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Review
. 2007 Jun 26;104(26):10753-4.
doi: 10.1073/pnas.0704357104. Epub 2007 Jun 20.

Breaking new ground to build bone

Lauren A Kingsley  1 , John M Chirgwin, Theresa A Guise
Affiliations
Review

Breaking new ground to build bone

Lauren A Kingsley et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
PYK2 signaling in osteoclasts (Left) and osteoblasts (Right). PYK2 is a negative regulator of osteoblast differentiation and activity. The unknown mechanism may involve inhibition of regulators of osteoblast function, Runx2, osterix, or Wnt signaling factors or stimulation of the inhibitor Dkk1. The role of PYK2 differs in osteoclasts: PYK2 null mice had normal osteoclast differentiation and activity, possibly caused by the compensatory activity of FAK. The PYK2 kinase inhibitor, PF-431386, may represent a novel treatment for osteoporosis in addition to other anabolic agents under development, such as sclerostin- and Dkk1-neutralizing antibodies, statins, strontium, and selective estrogen receptor modulators (SERMs).
See this image and copyright information in PMC

Comment on

References

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