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Review
. 2007 Jun;26(6):678-89.
doi: 10.1016/j.immuni.2007.05.009.

Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from

Avinash Bhandoola  1 , Harald von Boehmer, Howard T Petrie, Juan Carlos Zúñiga-Pflücker
Affiliations
Free article
Review

Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from

Avinash Bhandoola et al. Immunity. 2007 Jun.
Free article

Abstract

T cells developing in the thymus are derived from hematopoietic stem cells (HSCs) in the bone marrow (BM). Understanding the developmental steps linking multipotent HSCs to intrathymic T lineage-committed progenitors is important for understanding cancer in T lineage cells, improving T cell reconstitution after BM transplantation, and designing gene-therapy approaches to treat defective T cell development or function. Such an understanding may also help ameliorate immunological defects in aging. This review covers the differentiation steps between HSCs and committed T cell progenitors within the thymus.

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