Ribosomal proteins and the control of alphabeta T lineage development
- PMID: 17582347
- DOI: 10.1016/j.immuni.2007.06.001
Ribosomal proteins and the control of alphabeta T lineage development
Abstract
How do committed alphabeta T lineage cells undergo rapid proliferation and developmental progression during beta selection? A new study shows that a ribosomal protein, RPL22, promotes the survival of expanding alphabeta T cells.
Comment on
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Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint.Immunity. 2007 Jun;26(6):759-72. doi: 10.1016/j.immuni.2007.04.012. Epub 2007 Jun 7. Immunity. 2007. PMID: 17555992
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