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Review
. 2007 Jun;7(6):609-16.
doi: 10.2174/138955707780859422.

A search for inhibitors of S100B, a member of the S100 family of calcium-binding proteins

Joseph Markowitz  1 , Alexander D MacKerell Jr, David J Weber
Affiliations
Review

A search for inhibitors of S100B, a member of the S100 family of calcium-binding proteins

Joseph Markowitz et al. Mini Rev Med Chem. 2007 Jun.

Abstract

Typically, malignant melanoma has wild-type p53, and yet this cancer proliferates. S100B, which binds p53 and is up-regulated in melanoma, down-regulates wild-type p53 tumor suppressor function. Inhibitors of the S100B-p53 interaction were identified using computer aided drug design (CADD) combined with NMR methodologies and represent potentially new chemotherapeutics for melanoma.

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