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. 1991;6(4):288-92.
doi: 10.1002/mds.870060404.

Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate

T Z Aziz  1 , D Peggs, M A Sambrook, A R Crossman
Affiliations

Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate

T Z Aziz et al. Mov Disord. 1991.

Abstract

Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the subthalamic nucleus has therefore been performed in two primates with this condition and found to produce a remarkable amelioration of the disorder.

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