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Comment
. 2007 Jun;14(6):605-6.
doi: 10.1016/j.chembiol.2007.06.001.

Selective inhibition of CBP/p300 HAT

Vasiliki Sarli  1 , Athanassios Giannis
Affiliations
Comment

Selective inhibition of CBP/p300 HAT

Vasiliki Sarli et al. Chem Biol. 2007 Jun.

Abstract

In this issue of Chemistry & Biology, Mantelingu and colleagues present the development of the garcinol derivative LTK-14, which is a specific and nontoxic inhibitor of histone acetyltransferase p300-HAT [1]. Interestingly, it blocks histone acetylation of HIV-infected cells resulting in inhibition of the multiplication of HIV in these cells.

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