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. 1991 Oct:(10):19-22.

[Mutagenesis, induced by phosphotriester analogs of oligonucleotides and directed to the cleavage site of double-spiral DNA]

[Article in Russian]
V A Petrenko, L I Karpenko, S I Tat'kov, O Iu Smirnova, G A Kuz'micheva, A A Il'ichev
  • PMID: 1758470

[Mutagenesis, induced by phosphotriester analogs of oligonucleotides and directed to the cleavage site of double-spiral DNA]

[Article in Russian]
V A Petrenko et al. Mol Gen Mikrobiol Virusol. 1991 Oct.

Abstract

The mutagenic properties of phosphotriester analogues revealed in course of interaction with linearized plasmid DNA were studied. The plasmid-based model system permitting one to test reliably the induced mutations is proposed. The efficiency of mutagenesis was shown to depend on the length of the oligonucleotide-mutagen and the genotype of the transformed Escherichia coli strain. The possible mechanisms involved in mutagenesis are discussed.

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