Review
doi: 10.1016/j.neuint.2007.05.007.
Epub 2007 May 24.
The functions of UCH-L1 and its relation to neurodegenerative diseases
Affiliations
- PMID: 17586089
- DOI: 10.1016/j.neuint.2007.05.007
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Review
The functions of UCH-L1 and its relation to neurodegenerative diseases
Neurochem Int.
2007 Jul-Sep.
Abstract
Parkinson's disease (PD) and Alzheimer's disease (AD), the most common neurodegenerative diseases, are caused by both genetic and environmental factors. Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is involved in the pathogenesis of both of these neurodegenerative diseases. Several functions of UCH-L1, other than as an ubiquitin hydrolase, have been proposed; these include acting as an ubiquitin ligase and stabilizing mono-ubiquitin. This review focuses on recent findings on the functions and the regulation of UCH-L1, in particular those that relate to PD and AD.
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