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Review
. 2007 Jul-Sep;51(2-4):105-11.
doi: 10.1016/j.neuint.2007.05.007. Epub 2007 May 24.

The functions of UCH-L1 and its relation to neurodegenerative diseases

Rieko Setsuie  1 , Keiji Wada
Affiliations
Review

The functions of UCH-L1 and its relation to neurodegenerative diseases

Rieko Setsuie et al. Neurochem Int. 2007 Jul-Sep.

Abstract

Parkinson's disease (PD) and Alzheimer's disease (AD), the most common neurodegenerative diseases, are caused by both genetic and environmental factors. Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is involved in the pathogenesis of both of these neurodegenerative diseases. Several functions of UCH-L1, other than as an ubiquitin hydrolase, have been proposed; these include acting as an ubiquitin ligase and stabilizing mono-ubiquitin. This review focuses on recent findings on the functions and the regulation of UCH-L1, in particular those that relate to PD and AD.

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