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Comparative Study
. 2007 Sep;22(9):1254-9.
doi: 10.1007/s11606-007-0233-1. Epub 2007 Jun 22.

Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: results from the IN-RANGE study

Catherine S Parker  1 , Zhen Chen, Maureen Price, Robert Gross, Joshua P Metlay, Jason D Christie, Colleen M Brensinger, Craig W Newcomb, Frederick F Samaha, Stephen E Kimmel
Affiliations
Comparative Study

Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: results from the IN-RANGE study

Catherine S Parker et al. J Gen Intern Med. 2007 Sep.

Abstract

Background: Patient adherence to warfarin may influence anticoagulation control; yet, adherence among warfarin users has not been rigorously studied.

Objective: Our goal was to quantify warfarin adherence over time and to compare electronic medication event monitoring systems (MEMS) cap measurements with both self-report and clinician assessment of patient adherence.

Design: We performed a prospective cohort study of warfarin users at 3 Pennsylvania-based anticoagulation clinics and assessed pill-taking behaviors using MEMS caps, patient reports, and clinician assessments.

Results: Among 145 participants, the mean percent of days of nonadherence by MEMS was 21.8% (standard deviation+/-21.1%). Participants were about 6 times more likely to take too few pills than to take extra pills (18.8 vs. 3.3%). Adherence changed over time, initially worsening over the first 6 months of monitoring, which was followed by improvement beyond 6 months. Although clinicians were statistically better than chance at correctly labeling a participant's adherence (odds ratio = 2.05, p = 0.015), their estimates often did not correlate with MEMS-cap data; clinicians judged participants to be "adherent" at 82.8% of visits that were categorized as moderately nonadherent using MEMS-cap data (>or=20% nonadherence days). Similarly, at visits when participants were moderately nonadherent by MEMS, they self-reported perfect adherence 77.9% of the time.

Conclusions: These results suggest that patients may benefit from adherence counseling even when they claim to be taking their warfarin or the clinician feels they are doing so, particularly several months into their course of therapy.

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Figures

Figure 1
Figure 1
Distribution of the percent of days nonadherent (PMEMS,incorrect). There are 17 participants in the 0% group, 39 in the 0.1–10.0% group, 33 in the 10.1–20.0% group, 16 in the 20.1–30.0% group, 13 in the 30.1–40.0% group, 7 in the 40.1–50.0% group, and 20 in the >50% group.
Figure 2
Figure 2
Percent of days nonadherent (PMEMS,incorrect) vs. month after beginning warfarin use. The sample size for each month is indicated by n above each bar.
See this image and copyright information in PMC

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