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. 1976 Feb;56(2):235-9.
doi: 10.1111/j.1476-5381.1976.tb07447.x.

Hypothalamo-pituitary adrenocortical function in the rat after treatment with betamethasone

J C Buckingham, J R Hodges

Hypothalamo-pituitary adrenocortical function in the rat after treatment with betamethasone

J C Buckingham et al. Br J Pharmacol. 1976 Feb.

Abstract

1 Hypothalamo-pituitary-adrenocortical (HPA) activity was suppressed in rats treated with betamethasone. 2 Recovery of normal HPA function occurred after corticosteroid withdrawl. 3 Although corticotrophin release was rapidly restored to its basal rate there was a delay in the return of the normal adrenocorticotrophic response to stress and normal adrenocortical function was evident only after the plasma adrenocorticotrophic hormone had reached 'supra-normal' levels. 4 The physiological significance and possible clinical relevance of the results are discussed.

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