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. 2007 Aug 15;17(16):4428-31.
doi: 10.1016/j.bmcl.2007.06.024. Epub 2007 Jun 10.

Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol

Franck Amblard  1 , Baskaran Govindarajan, Benjamin Lefkove, Kimberly L Rapp, Mervi Detorio, Jack L Arbiser, Raymond F Schinazi
Affiliations

Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol

Franck Amblard et al. Bioorg Med Chem Lett. .

Abstract

A series of new bisphenol derivatives bearing allylic moieties were synthesized as potential analogs of honokiol and/or magnolol. Certain compounds exhibited specific anti-proliferation activity against SVR cells and moderate anti-HIV-1 activity in primary human lymphocytes. Compound 5h was the most potent compound and its anti-tumor activity was evaluated in vivo.

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