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Case Reports
. 2008 Jun;167(6):695-6.
doi: 10.1007/s00431-007-0547-3. Epub 2007 Jun 23.

The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever

Lorenzo Calligaris  1 , Federico Marchetti, Alberto Tommasini, Alessandro Ventura
Affiliations
Case Reports

The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever

Lorenzo Calligaris et al. Eur J Pediatr. 2008 Jun.

Abstract

Colchicine is the treatment of choice in familial Mediterranean fever (FMF) for the prevention of both attacks and secondary amyloidosis. The overall nonresponder rate is about 5-10%. Anakinra is known to have good effectiveness in a severe autoinflammatory syndrome [chronic infantile neurological cutaneous and articular (CINCA) syndrome] and other recurrent hereditary periodic fevers. Pyrin--the protein involved in FMF--has a role in activating the proinflammatory cytokine interleukin (IL)-1beta. We report the effectiveness of the addition of an IL-1-receptor inhibitor (anakinra) to colchicine in controlling the febrile attacks and acute phase response in an adolescent with FMF resistant to colchicine.

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References

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