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. 1976 Feb;36(2 pt 2):574-81.

The epidemiology and virology of C-type virus-associated hematological cancers and related diseases in wild mice

  • PMID: 175918

The epidemiology and virology of C-type virus-associated hematological cancers and related diseases in wild mice

M B Gardner et al. Cancer Res. 1976 Feb.

Abstract

In several different populations of wild mice, observed over a 35-month period in laboratory geriatric colonies, a direct correlation was found between the prevalence and titer of spleen complement-fixing gs (p30) antigen and C-type particles in newly trapped healthy mice and a predilection to lymphoma and a hind leg paralytic disease upon aging. Other studies have established the indigenous C-type virus as the essential etiological determinant of both diseases in wild mice. An increased incidence of breast carcinomas, hepatomas, and pulmonary adenomas associated with C-type virus also occurred in the lymphoma-paralysis-prone colony as compared with the tumor-resistant colonies.

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