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. 2007 Oct;28(7):891-5.
doi: 10.1097/MAO.0b013e3180dca1cc.

HLA-DRB1*1101 allele may be associated with bilateral Méniére's disease in southern European population

Jose A Lopez-Escamez  1 , Jose R Vilchez, Andres Soto-Varela, Sofia Santos-Perez, Herminio Perez-Garrigues, Ismael Aran, Miguel A Lopez-Nevot
Affiliations

HLA-DRB1*1101 allele may be associated with bilateral Méniére's disease in southern European population

Jose A Lopez-Escamez et al. Otol Neurotol. 2007 Oct.

Abstract

Objective: To analyze the associations of HLA-DRB1* and DQB1* Class II alleles in patients with bilateral Méniére's disease (MD).

Patients and methods: Eighty patients from two ethnically defined groups with definite bilateral MD, according to the diagnostic scale of the American Academy of Otolaryngology-Head and Neck Surgery, were compared with normal controls from the same origin in a prospective multicenter study. We performed an allele-specific amplification for HLA-DRB1* and DQB1* genes of the major histocompatibility complex.

Results: The allele HLA-DRB1*1101 was associated with bilateral MD in the Mediterranean population (odds ratio, 3.65 [95% confidence intervals, 1.5-9.1], corrected p = 0.029); however, this allele was not associated in the group from Galicia (northwest of Spain). No differences were found in the distribution of alleles for the gene HLA-DQB1* between patients and controls.

Conclusion: The allele HLA-DRB1*1101 and the allelic group HLA-DRB1*11 may determine an increased susceptibility to develop bilateral MD in a southern European population.

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