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. 2008 Apr;84(2):194-8.
doi: 10.1016/j.rvsc.2007.04.005. Epub 2007 Jun 25.

Transient correlation between viremia levels and IL-10 expression in pigs subclinically infected with porcine circovirus type 2 (PCV2)

L Darwich  1 , J Segalés, A Resendes, M Balasch, J Plana-Durán, E Mateu
Affiliations

Transient correlation between viremia levels and IL-10 expression in pigs subclinically infected with porcine circovirus type 2 (PCV2)

L Darwich et al. Res Vet Sci. 2008 Apr.

Abstract

Immunological impairment by porcine circovirus type 2 (PCV2) infection is well documented in pigs suffering from postweaning multisystemic wasting syndrome. Nonetheless, little is known about immune status of pigs that remain PCV2 subclinically infected. Thus, seven pigs successfully infected in an experimental inoculation and without developing disease and nine control non-inoculated pigs were examined. Serological, virological and immunological determinations were done throughout ten weeks post-infection (PI). At week 3 PI, inoculated animals presented the peak of viremia and produced higher levels of IL-10 than the controls; correlation between viral load and IL-10 amounts was observed (p<0.05). Also, the ratio IgM/IgG suffered a shift skewing IgM production towards an IgG response. By 10 weeks PI, levels of IL-10 disappeared and the viremia decreased. In summary, subclinically PCV2-infected pigs developed a transient PCV2-specific IL-10 response during the viremic phase of infection which coincided with the inversion of the IgM/IgG ratio.

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Figures

Fig. 1
Fig. 1
Serum antibodies (IgM and IgG) and IL-10 levels in front of the viremia evolution in subclinically PCV2-infected pigs.
Fig. 2
Fig. 2
Correlation plot between levels of IL-10 and the PCV2 load in blood of PCV2 subclinically infected pigs at 3 weeks PI. The Spearman correlation test was used to evaluate the r and p (two-tailed) values. Errors bars (95% of confidence interval) are represented in discontinuous line.
See this image and copyright information in PMC

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