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Comment
. 2008 Mar 15;27(6):831-44.
doi: 10.1002/sim.2972.

Global tests in the additive hazards regression model

Axel Gandy  1 , Terry M Therneau, Odd O Aalen
Affiliations
Comment

Global tests in the additive hazards regression model

Axel Gandy et al. Stat Med. .

Abstract

In this article, we discuss testing for the effect of several covariates in the additive hazards regression model. Bhattacharyya and Klein (Statist. Med. 2005; 24(14):2235-2240) note that an ad hoc weight function suggested by Aalen (Statist. Med. 1989; 8:907-925) is inconsistent when used as a global test for comparing groups since the test statistic depends on which group is used as the baseline group. We will suggest a simple alternative test that does not exhibit this problem. This test is a natural extension of the logrank test. We shall also discuss an alternative covariance estimator. The tests are applied to a data set and a simulation study is performed.

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