Metabolic syndrome in obese children born large for gestational age

Abstract

Objective: This study was to compare the prevalence of metabolic syndrome (MS) and insulin release in Chinese obese children born large-for-gestational age (LGA) with those born appropriate-for-gestational age (AGA).

Methods: Obese children were divided into LGA group (n = 60) and AGA group (n = 312); clinical and metabolic characteristics were collected. An oral glucose tolerance test was performed to detect glucose and insulin concentration at 0, 30, 60, 90 and 120 min. Differences between parameters were compared in the two groups and MS was determined.

Results: The age of adiposity rebound (AR) was earlier and the period from AR to hospitalization was longer in LGA group than AGA group (4.58 +/- 3.35 years vs 5.64 +/- 3.08 yr, p=0.016 and 5.87 +/- 2.85 yr, vs 4.98 +/- 2.7 yr, p=0.02). There were no differences in beta -cell function, insulin resistance, insulin sensitivity and Disposition index between the two groups. Fasting insulin (FINS) and area under curve of insulin (AUCI) showed differences between two groups. The prevalence of MS was 65% for LGA group, which was significantly higher than AGA group (42.3%). LGA status increased the risk of MS with hazard ratios of 2.53 [95% confidence intervals (CI): 1.42-4.51]. Timing of AR showed significant negative correlation with hypertriglyceridemia (r = -0.497, P = 0.01). Multiple logistic regression analysis identified age at AR as an independent factor associated with blood triglyceride level. The prevalence of hypertension and hypertriglyceridemia was independently associated with LGA [adjusted odds ratios (95% CI) 2.41 (1.39-4.36), P = 0.003; 2.18(1.21-3.72), P = 0.016].

Conclusion: There was a younger trend in age of AR in obese children born LGA. The prevalence of MS was particularly higher in obese pediatric populations born LGA. Hypertension and hypertriglyceridemia were better components for diagnosis of MS in obese children.