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Case Reports
. 2007 Sep;45(9):3086-8.
doi: 10.1128/JCM.00593-07. Epub 2007 Jun 27.

First contemporary case of human infection with Cryptococcus gattii in Puget Sound: evidence for spread of the Vancouver Island outbreak

Arlo Upton  1 , James A Fraser, Sarah E Kidd, Camille Bretz, Karen H Bartlett, Joseph Heitman, Kieren A Marr
Affiliations
Case Reports

First contemporary case of human infection with Cryptococcus gattii in Puget Sound: evidence for spread of the Vancouver Island outbreak

Arlo Upton et al. J Clin Microbiol. 2007 Sep.

Abstract

We report a case of cryptococcosis due to C. gattii which appears to have been acquired in the Puget Sound region, Washington State. Genotyping confirmed identity to the predominant Vancouver Island genotype. This is the first documented case of human disease by the major Vancouver Island emergence strain acquired within the United States.

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Figures

FIG. 1.
FIG. 1.
The Orcas Island strain is a VGIIa genotype isolate: MLST analysis of 28 loci revealed that isolate T67707 is identical in these genomic locations to the VGIIa isolates of Vancouver Island. The locations of each sequenced locus in the related C. neoformans JEC21 genome are shown, scattered over 11 of the 14 chromosomes. Loci in green are alleles common to the VGIIb genotype, found on VI and in Australia. Blue loci are unique to the VI VGIIa genotype.
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