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Case Reports
. 1991 Oct;21(5):742-3.
doi: 10.1111/j.1445-5994.1991.tb01381.x.

Fulminant metoclopramide induced neuroleptic malignant syndrome rapidly responsive to intravenous dantrolene

A Henderson  1 , P Longdon
Affiliations
Case Reports

Fulminant metoclopramide induced neuroleptic malignant syndrome rapidly responsive to intravenous dantrolene

A Henderson et al. Aust N Z J Med. 1991 Oct.

Abstract

We report a case of fulminant neuroleptic malignant syndrome in a man aged 70 developing within 12 hours of starting six-hourly intravenous metoclopramide. The muscle rigidity and hyperpyrexia were unresponsive to intravenous benztropine but resolved within one hour of intravenous dantrolene 2 mg/kg. Within six hours the patient had a partial relapse which resolved completely following further intravenous dantrolene 2 mg/kg. This case demonstrates that the rapid effect of intravenous dantrolene can be life saving in fulminant neuroleptic malignant syndrome.

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