Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Jul;62(7):638-49.
doi: 10.1136/thx.2004.031005.

Challenges in pulmonary fibrosis. 2: Bronchiolocentric fibrosis

Jean-François Cordier  1
Affiliations
Review

Challenges in pulmonary fibrosis. 2: Bronchiolocentric fibrosis

Jean-François Cordier. Thorax. 2007 Jul.

Abstract

Bronchiolocentric fibrosis is essentially represented by the pathological pattern of constrictive fibrotic bronchiolitis obliterans. The corresponding clinical condition (obliterative bronchiolitis) is characterised by dyspnoea, airflow obstruction at lung function testing and air trapping with characteristic mosaic features on expiratory high resolution CT scans. Bronchiolitis obliterans may result from many causes including acute diffuse bronchiolar damage after inhalation of toxic gases or fumes, alloimmune chronic processes after lung or haematopoietic stem cell transplantation, or connective tissue disease (especially rheumatoid arthritis). Airway-centred interstitial fibrosis and bronchiolar metaplasia are other features of bronchiolocentric fibrosis.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None.

References

    1. Reynaud A C. Mémoire sur l'oblitération des bronches. Mem Acad Med Paris 18354117–167.
    1. Lange W. Ueber eine eigenthümliche Erkrankung der kleinen Bronchien und Bronchiolen. (Bronchitis et Bronchiolitis obliterans). Dtsch Arch Klin Med 190170342–364.
    1. Fraenkel A. Ueber Bronchiolitis fibrosa obliterans, nebst Bemerkungen über Lungenhyperämie une indurirende Pneumonie. Dtsch Arch Klin Med 190273484–510.
    1. Urbanski S J, Kossakowska A E, Curtis J.et al Idiopathic small airways pathology in patients with graft‐versus‐host disease following allogeneic bone marrow transplantation. Am J Surg Pathol 198711965–971. - PubMed
    1. Yousem S A. The histological spectrum of pulmonary graft‐versus‐host disease in bone marrow transplant recipients. Hum Pathol 199526668–675. - PubMed

MeSH terms