Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Feb;27(1):6-9.

Non-Hodgkin's lymphoma of nasal cavity and paranasal sinuses. A clinicopathological and immunohistochemical study

T Chalastras  1 , A Elefteriadou, J Giotakis, K Soulandikas, S Korres, E Ferekidis, D Kandiloros
Affiliations

Non-Hodgkin's lymphoma of nasal cavity and paranasal sinuses. A clinicopathological and immunohistochemical study

T Chalastras et al. Acta Otorhinolaryngol Ital. 2007 Feb.

Abstract
in English, Italian

Aim of this study was to investigate the clinical characteristics, management and prognosis of non-Hodgkin lymphomas of the nasal cavity and paranasal sinuses. Overall 12 patients with non-Hodgkin malignant lymphoma, at our Institute, were studied over an eight-year period from 1997 to 2005. Patients' data collected were age, sex, presenting signs and symptoms, histology, treatment, complications, and outcome. Also available were computerised tomography findings, and paraffin-embedded tissue bocks. Mean age was 62 years (range: 42-81), with a male dominance (male to female ratio: 7:5). Most patients had not presented any specific symptoms, such as nasal obstruction, headaches, epistaxis and facial swelling. Using immunocytochemistry on paraffin-embedded tissue sections, the predominance of large B-cell subtype was detected. Treatment administered: only radiotherapy (stage IEA) or in combination with chemotherapy (IIE-IVE). Of these patients, 5 died from the disease, 4 survived without disease, 2 survived with the disease, and one died of non-related causes. Non-Hodgkin's lymphomas are relatively rare. Early diagnosis, based mainly on tissue biopsy and computerised tomography, is essential in the management of non-Hodgkin lymphoma.

Lo scopo della presente ricerca era di studiare le caratteristiche cliniche, il trattamento e la prognosi del linfoma non-Hodgkin (NHL) della cavità nasale e dei seni paranasali. Sono stati studiati 12 pazienti con NHL, che si sono ricoverati presso il nostro ospedale, durante un periodo di 8 anni dal 1997 al 2005. I dati raccolti comprendono l’età, il sesso, i segni e i sintomi di esordio, l’esame istologico, il trattamento, le complicazioni e l’esito finale. L’età media dei pazienti è di 62 anni (range: 42-81 anni) con il sesso maschile dominante (maschi/femmine ratio: 7/5). La maggior parte dei pazienti presentava sintomi non specifici come epistassi, cefalea, senso di tensione nasale ed edema facciale. Dal punto di vista immunoistochimico c’era la predominanza delle cellule B. In tutti i casi è stata eseguita la radioterapia, come monoterapia (stadio IEA), o in combinazione con la chemioterapia (IIE-IVE). Cinque pazienti sono deceduti, quattro sono sopravvissuti liberi da malattia, due sono sopravvissuti con la malattia e uno è deceduto per altre cause. Il linfoma non-Hodgkin del naso e dei seni paranasali è relativamente raro. La diagnosi precoce, che si basa soprattutto sulla biopsia tissutale e la tomografia computerizzata, è essenziale per il trattamento dei NHL.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Coronal computer tomography scan shows mass occupying ethmoid and maxillary sinuses together with nasal cavities.
Fig. 2
Fig. 2
Axial computer tomography scan shows mass occupying ethmoid and maxillary sinuses, which extends to adjacent nasal cavity.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Shohat I, Berkowicz M, Dori S, Horowitz Z, Wolf M, Taicher S, et al. Primary non-Hodgkin’s lymphoma of the sinonasal tract. Oral Surg Oral Med Oral Pathol 2004;97:328-31. - PubMed
    1. Harris N, Jaffe E, Stein H, Banks P, Chan J, Cleary M, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994;84:1361-92. - PubMed
    1. Stansfeld A, Diebold J, Kapanci Y, Kelenyi G, Lennert K, Mioduszewka O, et al. Updated Kiel classification for lymphomas. Lancet 1988;1:292-3. - PubMed
    1. National Cancer Institute sponsored study of classifications of non-Hodgkin’s lymphomas: summary and description of a working formulation for clinical usage. The non-Hodgkin’s lymphoma pathologic classification project. Cancer 1982;49:2112-35. - PubMed
    1. Wang J, Sun N, Weinstein S, Canalis R. Primary T-cell-Rich B-cell lymphoma of the ethmoid sinus. A case report with 5 years of follow-up. Arch Path Lab Med 2000;124:1213-6. - PubMed

LinkOut - more resources