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Case Reports
. 2007 Dec;58(3):411-3.
doi: 10.1016/j.lungcan.2007.05.014. Epub 2007 Jun 29.

Sequential occurrence of non-small cell and small cell lung cancer with the same EGFR mutation

Ryotaro Morinaga  1 , Isamu Okamoto, Kazuyuki Furuta, Yukiko Kawano, Masaru Sekijima, Kensaku Dote, Takao Satou, Kazuto Nishio, Masahiro Fukuoka, Kazuhiko Nakagawa
Affiliations
Case Reports

Sequential occurrence of non-small cell and small cell lung cancer with the same EGFR mutation

Ryotaro Morinaga et al. Lung Cancer. 2007 Dec.

Abstract

We report a case of small cell lung cancer (SCLC) developing after prolonged treatment (more than 2 years) for primary adenocarcinoma of the lung, and we show that both the SCLC and non-small cell lung cancer (NSCLC) tissues obtained from the same site share the same deletion in exon 19 of EGFR. This case suggests that the activating EGFR mutations may confer the pathogenesis of a subset of SCLC.

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