[Syntheses and biological activities of glycoconjugates]

Abstract

This review describes the oligosaccharide syntheses and biological activities of glycosphingolipids, focusing especially on those found in invertebrates like millipedes, nematoda parasites, and cestoda parasites, and model compounds related to a major antigenic epitope against antibupleurum 2IIc/PG-1-IgG from antiulcer pectic polysaccharides. A novel and simple approach for the rational design of glycoclusters and glycodendrimers by coupling with a sugar unit and a cluster unit, was developed with beta-alanine derivatives used to construct the latter compounds.