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. 2007 Jul;8(7):616-21.
doi: 10.1038/sj.embor.7401022.

Microbes have the last word. A drastic re-evaluation of antimicrobial treatment is needed to overcome the threat of antibiotic-resistant bacteria

Julian Davies  1
Affiliations

Microbes have the last word. A drastic re-evaluation of antimicrobial treatment is needed to overcome the threat of antibiotic-resistant bacteria

Julian Davies. EMBO Rep. 2007 Jul.
No abstract available

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Figures

Figure 1
Figure 1
The relationship between antibiotic-resistance development in Shigella dysentery isolates in Japan and the introduction of antimicrobial therapy between 1950 and 1965. In 1955, the first case of plasmid-determined resistance was characterized. MDR, multidrug resistance.
Figure 2
Figure 2
The biological cost of antibiotic resistance and its genetic compensation.
Figure 3
Figure 3
The integron mechanism of antibiotic-resistance gene cassette acquisition. The integron integrase is responsible for the integration of circular-resistance gene cassettes. It does this by catalysing site-specific recombination between the att sites on the gene cassette and the plasmid. Cassette clusters are assembled in linear arrays. (Drawing provided by P. Courvalin.) AttC, attachment site (cassette); attI, attachment site (integron); intl1, integrase 1; Pant, promoter for gene cassette expression; qac, quaternary ammonium compound resistance; sul, sulphonamide resistance.
None
See this image and copyright information in PMC

References

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