Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Feb;28(1):11-7.

Hepatorenal syndrome

Charles K F Ng  1 , Michael H M Chan, Morris H L Tai, Christopher W K Lam
Affiliations

Hepatorenal syndrome

Charles K F Ng et al. Clin Biochem Rev. 2007 Feb.

Abstract

Hepatorenal syndrome (HRS) is a serious complication of liver cirrhosis with critically poor prognosis. The pathophysiological hallmark is severe renal vasoconstriction, resulting from complex changes in splanchnic and general circulations as well as systemic and renal vasoconstrictors and vasodilators. Rapid diagnosis and management are important, since recent treatment modalities including vasoconstrictor therapy can improve short-term outcome and buy time for liver transplantation, which can result in complete recovery.

PubMed Disclaimer

Figures

Figure
Figure
Pathogenesis of HRS (adapted from References and 17).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Frerichs FT. Tratado practico de las Enfermedades del Hígado, de los Vasos Hepaticos y de las Vias Biliares. Madrid: Libreria Extranjera y Nacional, cientifíca y Literaria, 1877.
    1. Flint A. Clinical report on hydro-peritoneum based on an analysis of forty-six cases. Am J Med Sci. 1863;45:306–39.
    1. Hecker R, Sherlock S. Electrolyte and circulatory changes in terminal liver failure. Lancet. 1956;2:1221–5. - PubMed
    1. Koppel MH, Coburn JN, Mims MM, Goldstein H, Boyle JD, Rubini ME. Transplantation of cadaveric kidneys from patients with hepatorenal syndrome. Evidence for the functional nature of renal failure in advanced liver disease. N Engl J Med. 1969;280:1367–71. - PubMed
    1. Iwatsuki S, Popovtzer MM, Corman JL, et al. Recovery from hepatorenal syndrome after orthotopic liver transplantation. N Engl J Med. 1973;289:1155–9. - PMC - PubMed

LinkOut - more resources