Review
doi: 10.1016/j.cell.2007.06.017.
Immortal strands? Give me a break
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- PMID: 17604711
- DOI: 10.1016/j.cell.2007.06.017
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Review
Immortal strands? Give me a break
Cell.
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Abstract
The "immortal strand" hypothesis proposes that asymmetrically dividing stem cells selectively retain chromosomes containing "old" DNA to prevent accumulation of mutations. As I describe in this Essay, such a possibility seems unlikely. An alternative explanation is that asymmetric cell divisions and cell fate are codirected by epigenetic differences between sister chromatids.
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