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Review
. 2007 Jun 29;129(7):1255-7.
doi: 10.1016/j.cell.2007.06.018.

The primary cilium: keeper of the key to cell division

Junmin Pan  1 , William Snell
Affiliations
Free article
Review

The primary cilium: keeper of the key to cell division

Junmin Pan et al. Cell. .
Free article

Abstract

Assembly of the nonmotile primary cilium of vertebrate cells requires one of the centrioles of the centrosome. A cluster of new studies, including one in this issue of Cell by Pugacheva et al. (2007), reveal that ciliary assembly proteins influence cell-cycle progression and that a centrosomal "mitotic kinase" promotes ciliary disassembly. The link between the cell cycle and the primary cilium may reflect a requirement for liberation of the ciliary centriole to allow the centrosome to form the mitotic spindle.

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