Case Reports
doi: 10.1111/j.1399-3062.2007.00243.x.
Epub 2007 Jul 1.
Viral monitoring and successful treatment of a ganciclovir-resistant cytomegalovirus infection in a heart transplant recipient
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- PMID: 17605746
- DOI: 10.1111/j.1399-3062.2007.00243.x
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Case Reports
Viral monitoring and successful treatment of a ganciclovir-resistant cytomegalovirus infection in a heart transplant recipient
Transpl Infect Dis.
2008 Apr.
Abstract
We reported a ganciclovir (GCV)-resistant cytomegalovirus (CMV) infection in a heart transplant recipient. Genotypic and phenotypic susceptibility assays demonstrated an A594V mutation in the UL97 phosphotransferase gene and GCV IC(50)>96 microM. Low GCV concentration exposure, immunosuppressive treatment, donor-positive/recipient-negative CMV serostatus, viral reactivations within antiviral prophylaxis or treatment, contributed to GCV-resistant strain selection.
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