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. 2007 Jul 2:4:15.
doi: 10.1186/1477-7800-4-15.

Simultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic Cushing's syndrome

Michael Sand #  1 , Samuel Uecker #  1 , Falk G Bechara  2 , Marcos Gelos  1 , Daniel Sand  3 , Till H Wiese  4 , Benno Mann  1
Affiliations

Simultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic Cushing's syndrome

Michael Sand et al. Int Semin Surg Oncol. .

Abstract

Medullary thyroid carcinomas (MTC) constitute about 5 to 7 % of thyroid neoplasms. They originate from parafollicular C-cells which can secrete adrenocorticotropic hormone (ACTH) and/or corticotropin-releasing factor (CRF) in abnormally high concentrations, potentially causing paraneoplastic Cushing's Syndrome (CS). We report on a 42-year-old male patient with a ten year history of metastatic medullary thyroid carcinoma suffering from paraneoplastic Cushing's Syndrome caused by ectopic hypersecretion of ACTH and a simultaneous Cortisol producing adrenal metastasis.

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Figures

Figure 1
Figure 1
Abdominal CT scan demonstrating the horizontal (a), coronal (b) and sagittal (c) section of a tumor in the left adrenal gland (circle).
See this image and copyright information in PMC

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