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. 2007 Aug 15;17(16):4432-6.
doi: 10.1016/j.bmcl.2007.06.022. Epub 2007 Jun 10.

N-(5-chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as gamma-secretase inhibitors

Michael F Parker  1 , Donna M Barten, Carl P Bergstrom, Joanne J Bronson, Jason A Corsa, Milind S Deshpande, Kevin M Felsenstein, Valerie L Guss, Steven B Hansel, Graham Johnson, Daniel J Keavy, Wai Y Lau, Jeremy Mock, C V C Prasad, Craig T Polson, Charles P Sloan, David W Smith, Owen B Wallace, Henry H Wang, Andrew Williams, Ming Zheng
Affiliations

N-(5-chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as gamma-secretase inhibitors

Michael F Parker et al. Bioorg Med Chem Lett. .

Abstract

A series of N-alkylbenzenesulfonamides were developed from a high throughput screening hit. Classic and parallel synthesis strategies were employed to produce compounds with good in vitro and in vivo gamma-secretase activity.

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