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. 2007 Jul;92(7):974-7.
doi: 10.3324/haematol.11051.

Chronic myelomonocytic leukemia in the light of the WHO proposals

Ulrich Germing  1 , Corinna Strupp, Sabine Knipp, Andrea Kuendgen, Aristoteles Giagounidis, Barbara Hildebrandt, Carlo Aul, Rainer Haas, Norbert Gattermann, John M Bennett
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Free article

Chronic myelomonocytic leukemia in the light of the WHO proposals

Ulrich Germing et al. Haematologica. 2007 Jul.
Free article

Abstract

The WHO classification moved CMML to myeloproliferative/myelodysplastic disorders, and defined CMML I and CMML II according to medullary and peripheral blast count. To confirm these proposals, we analyzed 266 patients with CMML I and 73 patients with CMML II. Median survival time was 20 months for CMML I, and 15 months for CMML II (p<0.005). The cumulative risk of AML evolution differed between patient groups (p=0,001). No conclusive differences in clinical, morphologic, hematologic or cytogenetic parameters were found. These data support the WHO proposals for the classifi-cation of CMML.

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