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. 2007 Jul;92(7):998-9.
doi: 10.3324/haematol.10327.

FCgammaRIIIA and FCgammaRIIA polymorphisms are not associated with response to rituximab and CHOP in patients with diffuse large B-cell lymphoma

Zdravko Mitroviç  1 , Igor Aurer, Ivo Radman, Radmila Ajdukoviç, Jadranka Sertiç, Boris Labar
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Free article

FCgammaRIIIA and FCgammaRIIA polymorphisms are not associated with response to rituximab and CHOP in patients with diffuse large B-cell lymphoma

Zdravko Mitroviç et al. Haematologica. 2007 Jul.
Free article

Abstract

We investigated the association ofFcgammaRIIIaa and FcgRIIa polymorphisms and response to R-CHOP in 58 patients with diffuse large B-cell lymphoma (DLBCL). FcgammaRIIIa and FcgRIIa polymorphisms did not influence response, event-free or overall survival. These results suggest that ADCC via FcgammaRIIIa and FcgammaRIIa may not be the major mechanism of activity of the R-CHOP combination in DLBCL.

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