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Review
. 1995 Aug;1(5):248-53.
doi: 10.1016/s1357-4310(95)91551-6.

Rapid viral quasispecies evolution: implications for vaccine and drug strategies

I S Novella  1 , E Domingo, J J Holland
Affiliations
Review

Rapid viral quasispecies evolution: implications for vaccine and drug strategies

I S Novella et al. Mol Med Today. 1995 Aug.

Abstract

High mutation rates occurring during replication allow RNA viruses to evolve rapidly and adapt continuously to new environments. This poses an enormous challenge to vaccine and drug development which, to be effective, must consider RNA virus variability and follow approaches that minimize the probability of escape or resistant mutants arising.

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