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Review
. 2007 Apr;27(2):90-3.

Subcutaneous benign fibrous histiocytoma of the cheek. Case report and review of the literature

C E Skoulakis  1 , C E Papadakis, G E Datseris, E I Drivas, D E Kyrmizakis, J G Bizakis
Affiliations
Review

Subcutaneous benign fibrous histiocytoma of the cheek. Case report and review of the literature

C E Skoulakis et al. Acta Otorhinolaryngol Ital. 2007 Apr.

Abstract
in English, Italian

Fibrous histiocytoma is a benign tumour composed of a mixture of fibroblastic and histiocytic cells. Based on the location of this tumour, fibrous histiocytoma are usually divided into cutaneous types and those involving deep tissues. These lesions most often arise on the skin, but may rarely occur in soft deep tissues. The diagnosis of fibrous histiocytoma may be clinically difficult when the lesion is located in the deep tissues, and is frequently confirmed after local excision. The most important diagnostic distinction is the separation of this tumour from aggressive forms of fibrohistiocytic neoplasms, including dermatofibrosarcoma protuberans and malignant fibrous histiocytoma. A 19-year-old male presented with a painless swelling on the right cheek. Detailed clinical and laboratory examinations were performed. The lesion had been totally excised under local anaesthesia, and histopathology revealed a benign fibrous histiocytoma. The diagnosis, location, treatment and prognosis of fibrous histiocytoma are also discussed.

Il fibroma istiocitario è un tumore benigno composto da fibroblasti e istiociti. In base alla sede di questo tumore, i fibromi istiocitari sono divisi solitamente nei tipi cutanei ed in quelli che coinvolgono i tessuti profondi. Queste lesioni si presentano spesso sulla cute, mentre possono riscontrarsi raramente nei tessuti molli profondi. La diagnosi clinica del fibroma istiocitario può essere difficile quando la lesione è situata in profondità e frequentemente se ne ha conferma solo dopo l’asportazione. La distinzione diagnostica più importante è la differenziazione di questo tumore dalle forme aggressive del tumore fibroistiocitario, compreso il dermatofibrosarcoma protuberans e l’istiocitoma fibroso maligno. Caso clinico: un paziente maschio di 19 anni si presenta con tumefazione non dolorosa alla guancia destra. Vengono effettuati gli esami di laboratorio e clinici. La lesione viene completamente asportata in anestesia locale. L’esame istologico ha rivelato un istiocitoma fibroso benigno. Sono discussi la diagnosi, la sede, il trattamento e la prognosi del fibroma istiocitario.

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Figures

Fig. 1
Fig. 1
CT scan shows homogenous enhancement of mass on right cheek.
Fig. 2
Fig. 2
Irregularly arranged collagen fibres mixed with scattered proliferating fibroblasts (Histiocytoma, fibrous type), X200, H + E.
Fig. 3
Fig. 3
Immunohistochemical staining demonstrated positivity for CD68 (A) and Vimentin (B), and negativity for smooth muscle actin (SMA) (C) and S-100 (D).
See this image and copyright information in PMC

References

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